Hodinový prehľad - Zdravotnícke a vedecké zaujímavosti

Súhrn: TOPLINE: Monthly rifampin-moxifloxacin-minocycline (RMM) therapy was associated with a lower risk for type 1 immunologic reactions than multidrug therapy (MDT) in patients with leprosy (Hansen disease [HD]) in a study METHODOLOGY: - Researchers conducted a retrospective cohort study of 111 patients with biopsy- and polymerase chain reaction-confirmed HD treated at a Miami HD clinic between October 2010 and November 2025 - The mean age of the patients was 52 years (range, 15-85 years); 62% were male; 40%-43% were Hispanic, 52%-56% were non-Hispanic, 9%-12% were Black or African American, and 84%-88% were White; 70% had multibacillary disease.

Súhrn: FDA issued a warning letter to medical device maker Medline over violations of manufacturing quality standards, the second such action against the company in two months June 3 (Reuters) - The U The Food and Drug Administration, in its letter dated May 28, said the company failed to thoroughly investigate microbial contamination incidents in finished drug products and also cited inadequate cleaning practices.

Súhrn: “Serum and biopsies do not always have to be the only sources of valid biologic samples for immune-mediated diseases ” Biopsies are highly invasive, and blood-based measurements do not always accurately reflect disease activity within the affected organs New Phenotype Examining saliva in patients with Sjögren syndrome is a logical approach because it originates from one of the organs most directly affected by the disease.

Súhrn: Mothers with overweight or obesity exposed to semaglutide before and during pregnancy had higher risks for excessive gestational weight gain, gestational diabetes, excessive fetal growth, and cesarean delivery than nonusers, a national database study in Obstetrics and Gynecology found Study investigators led by Yang Yu, PhD, MPH, MNS, an assistant professor at the University of Rochester School of Nursing in Rochester, New York, noted that current drug labeling advises discontinuing the drug at least 2 months before attempting to conceive, a warning based on animal research linking use in pregnancy to miscarriage, impaired fetal growth, and congenital anomalies However, unintended exposure during pregnancy is likely common, given the growth of GLP-1 use in reproductive-age women because strict contraceptive use is not mandated during treatment and approximately 40% of US pregnancies are unplanned.

Súhrn: Americký minister zahraničia Marco Rubio v stredu vyhlásil, že v kontexte spravodajských služieb ešte nepočul meno Bill Pulte Toho prezident Donald Trump v utorok vymenoval za dočasného riaditeľa národných spravodajských služieb USA, píše TASR podľa správy agentúry Reuters - Americký minister zahraničia Marco Rubio nepoznal meno Billa Pulteho v spravodajstve.